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Syrup septran pediatric dose : For infants 6 to 12 months of age: 6 grams/kg/dose For children 14 to 18 months of age: 10 grams/kg/dose For children 19 to 36 months of age: 15 grams/kg/dose For children 37 to 60 months of age: or maximum recommended dose of 30 grams/kg/dose and the minimum rate of 25 mL/kg/dose Hepatotoxicity Anaphylaxis Anaphylactic reactions in children have been reported following the administration of insulin to diabetic patients. The incidence of this adverse event increases with the dose given, but appears to be less frequent with doses below 100 mg/kg (1). The incidence of this adverse event increases with increasing glycemic control, but appears to respond high-dose insulin treatment more than to therapy with a low-dose bolus. This adverse reaction usually has a latency period of several minutes, and most persons with such an allergic reaction usually are able to take insulin as usual for 30 to 60 minutes after exposure IgE-reactive food antigens. A large proportion of patients with anaphylaxis also develop a moderate to severe rash. The median time of this allergic reaction is about 3 to 4 hours after the dose was given (2, 3). The incidence of this reaction in association with the use of high-dose insulin varies widely, which is of concern in view its potentially dangerous consequences. However, in patients diagnosed with diabetes mellitus, this reaction is most common in infants (< 1 year of age), whereas it is less frequent in adolescents and older persons (2, 4). The dose of first bolus, taken before the patient begins a higher-dose regimen, appears to be useful in reducing the risk for reactions (2, 5). The following table compares incidence of anaphylaxis in response to insulin with that observed in children asthma (i.e., who had not responded to an antigens-specific allergen). Prevention of anaphylaxis Because of the risk for anaphylaxis associated with the use of high-intensity insulin in children with diabetes, and the fact that this risk is higher in adolescents and elderly persons, low levels of insulin should be recommended (6). In addition, high dietary and environmental antigens can aggravate the underlying conditions of persons with diabetes (7). A new antigens-antibody-specific allergen was described in 1986. These antibodies are not detectable in the serum but are produced in the skin and mucous membranes. It is presumed that the allergen lipophilic and is not easily destroyed by the enzymes present in liver, although high levels of lipoproteins are believed to be involved in the development of anaphylaxis (8). These antibodies, as well those from other types of antigens, do not produce an anaphylactic reaction when they are administered alone to persons with diabetes. In this context, it is useful to note that in a clinical trial obese patients with type 2 diabetes, it was demonstrated that the oral administration of an antigens-antibody-specific IgE-antigen combination can lower serum IgE from a range of 40 to 50 Kg/L (4). The risk for anaphylaxis following initiation of a diet is very low. In a clinical study, the incidence of anaphylaxis related to the application of oral antigens-antibody-specific food antigens was very low, 0.5% compared with 8-15% in Doxylamine 40 Pills $251 - $229 Per pill other experimental groups (9, 10). A significant decrease in serum IgE was observed after 6 days of food challenge following the administration of a single dose consisting an oral antigens-antibody-specific product containing either a peptide or the same combined with a protein fragment containing IgE (11). Efficacy and Safety of Insulin in Children The efficacy of high-intensity insulin has been demonstrated in a randomized, double-blind, placebo-controlled trial in children with noninsulin-dependent diabetes mellitus. The total daily dose administered was 0.13 kg (10 kg) of glucose-substrate-substituted insulin, which is equivalent to 120 mg/kg, as reported previously (12). The study was designed to compare the effects of high-intensity insulin against a placebo or single oral dose of high-dose insulin. A total 80 children aged 6 to 17 years were included in the primary analysis and a total of 96 children in the secondary analysis. number of patients receiving insulin in the double-blind, placebo-controlled protocol was similar across age groups and was not significantly affected by the use Bringing viagra from mexico to us of a placebo (data not shown). The results of an analysis individual children with type 2 diabetes were similar to those observed previously in both groups (12).

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